The FTA-ABS test is used to detect antibodies to the bacteria Treponema pallidum, which causes syphilis.
Fluorescent treponemal antibody absorption test
A blood sample is needed.
No special preparation is necessary.
When the needle is inserted to draw blood, some people feel moderate pain. Others feel only a prick or stinging. Afterward, there may be some throbbing or a slight bruise. This soon goes away.
This test is done routinely to confirm whether a positive screening test for syphilis (either VDRL or RPR) means you have a current syphilis infection.
It may also be done when other syphilis tests are negative, to rule out a possible false-negative result.
A negative or nonreactive result means that you do not have a current or past infection with syphilis.
Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or test different samples. Talk to your health care provider about the meaning of your specific test results.
A positive FTA-ABS is often a sign of a syphilis infection. This test result will remain positive for life even if syphilis has been adequately treated. Therefore, it cannot be used to monitor the treatment of syphilis or determine that you have active syphilis.
Other illnesses, such as yaws and pinta (two other kinds of skin diseases), may also result in positive FTA-ABS results. Sometimes, there can be a false-positive result, most often in women with lupus.
There is little risk involved with having your blood taken. Veins and arteries vary in size from one person to another and from one side of the body to the other. Taking blood from some people may be more difficult than from others.
Other risks associated with having blood drawn are slight, but may include:
Radolf JD, Tramont EC, Salazar JC. Syphilis (Treponema pallidum). In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 9th ed. Philadelphia, PA: Elsevier; 2020:chap 237.
US Preventive Services Task Force (USPSTF); Bibbins-Domingo K, Grossman DC, et al. Screening for syphilis infection in nonpregnant adults and adolescents: US Preventive Services Task Force recommendation statement. JAMA. 2016;315(21):2321-2327. PMID: 27272583 www.ncbi.nlm.nih.gov/pubmed/27272583.